A Prospective Study about Application of Adapalene-benzoyl Peroxide-MLE Fixed Dose Combination Gel for the Treatment of Disease in Patients with Acne Vulgaris / 대한피부과학회지

Background@#Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit. Adapalene-benzoyl peroxide gel has been proven to be effective in the treatment of both inflammatory and comedonal acne. However, skin irritation characterized by erythema, scaling, and dryness may occur with the use of this formula. @*Objective@#This study aimed to investigate the effects and safety of a new formulation of adpalene-benzoyl peroxide in combination with multi-lamellar emulsion (MLE) for acne treatment. Methods: All patients were treated with adapalene-benzoyl peroxide with MLE once daily for 12 weeks on acne lesions. The subjects visited the hospital at baseline, 2 weeks, 4 weeks, 8 weeks, and 12 weeks, and clinical effects, patient satisfaction, and adverse effects were estimated. The severity of adverse effects was measured on a 4-point scale. @*Results@#A total of 30 subjects were enrolled. The number of lesions decreased significantly from 20.2 to 7.8 (p＜ 0.0001) after treatment. Investigator’s global assessment showed almost clear, and patient satisfaction increased from 3.57 to 4.13. The subjects had adverse effects such as tingling sensation (83.3%), scales (80.0%), erythema (63.3%), and dryness (63.3%). Severity of adverse effects had 1 point on average. Additionally, transepidermal water loss was found to be decreased. @*Conclusion@#This study suggests that adapalene-benzoyl peroxide with MLE is effective for treating acne lesions and shows high patient satisfaction. Hence, this new combination could be a safe and well-tolerated option for acne treatment.

Analysis of Dermatologic Diseases in Patients Receiving Anticancer Treatments: A Retrospective Study of 140 Cases / 대한피부과학회지

BACKGROUND: A number of anticancer agents are known to induce many adverse reactions in the skin. Related cutaneous adverse drug reactions influence the morbidity, mortality, and anti-cancer regimen of the patients. A multidisciplinary approach to cancer management has been emphasized. OBJECTIVE: To identify the causative anticancer agents and frequency of adverse reactions in the skin. METHODS: We retrospectively reviewed the medical records of patients who consulted at the Dermatology Department of Busan Paik Hospital and Haeundae Paik Hospital from January 2013 to February 2015. RESULTS: A total of 140 patients were enrolled. Among the 45 patients treated with antimetabolite analogs (30 cytarabine, 7 gemcitabine, 3 methotrexate, 2 fludarabine, 2 doxifluridine, and 1 decitabine), exanthematous drug eruption (49.1%) was the most common reaction, followed by hand-foot syndrome (28.3%). Among the 35 patients treated with fluorouracil (22 5-fluorouracil and 13 capecitabine), hand-foot syndrome (47.2%) was the most common, followed by acneiform eruption (25.0%). Among the 24 patients treated with epidermal grow factor receptor inhibitors (10 erlotinib, 10 cetuximab, and 4 gefitinib), acneiform eruption (54.8%) was the most common, followed by xerosis (19.4%). Among the 11 patients treated with anthracyclines (9 doxorubicin, 1 daunorubicin, and 1 idarubicin), acneiform eruption (45.5%) was the most common, followed by hand-foot syndrome (36.4%). Among the 7 patients treated with taxanes (4 docetaxel and 3 paclitaxel), hand-foot syndrome (42.8%) was the most common. Among the 6 patients treated with angiogenesis-inducing inhibitors (3 sorafenib, 2 pazopanib, and 1 sunitinib), hand-foot skin reaction (66.7%) was the most common. Only 2 patients (1.4%) changed treatments due to intolerable skin reactions. CONCLUSION: Clinicians should be aware of the various skin reactions of anticancer agents and predict their clinical course effectively.

Comparison of the Efficacy of Systemic Antibiotics and Systemic Retinoids in Hidradenitis Suppurativa / 대한피부과학회지

BACKGROUND: Hidradenitis suppurativa is a chronic inflammatory skin disease showing recurrent painful nodules and abscesses. Many treatment modalities, such as topical antibiotics, systemic antibiotics, retinoids, immunomodulators, biologics, and surgical treatment are used to treat the disease, but there is no single effective treatment for hidradenitis suppurativa. OBJECTIVE: We conducted this study to compare the clinical outcomes of treatment with systemic antibiotics and systemic retinoids. METHODS: We analyzed the clinical features, treatment modalities, and clinical outcomes of patients with hidradenitis suppurativa and compared the clinical outcomes of treatment modalities. RESULTS: A total of 77 patients were enrolled. Male patients were predominant, and the mean age was 28.1 years. Buttock (42.0%) was the most commonly affected site and 63 patients (81.8%) had lesions at Hurley stage I. Forty-eight patients (62.3%) were treated with systemic antibiotics and 29 (37.7%) with systemic retinoid. Seventy-one patients (92.2%) showed improvement after a mean treatment duration of 8.3 weeks, and 69 (89.6%) experienced recurrence after improvement. Systemic antibiotics showed a relatively high improvement rate, short mean treatment duration, and low recurrence rate compared with systemic retinoids, but the differences were not statistically significant. Among systemic antibiotics, both tetracycline and macrolide showed good therapeutic effects for HS, but the differences were also not statistically significant. CONCLUSION: In this study, systemic antibiotics were associated with superior treatment outcomes compared to systemic retinoids, though without statistical significance. In the case of mild lesions, treatment with systemic retinoids appears to show comparable effectiveness to systemic antibiotics.

Palmoplantar Pustulosis Induced by both Adalimumab and Golimumab for Treatment of Ankylosing Spondylitis

No abstract available.

A Case an Angioleiomyoma Occurring on the Labial Mucosa / 대한피부과학회지

No abstract available.

An Unusual Case of Generalized Molluscum Contagiosum Occurring after Psychosocial Stress in an Immunocompetent Adult / 대한피부과학회지

No abstract available.

A Case of Verruca Vulgaris Treated with Imiquimod / 대한피부과학회지

Despite numerous therapeutic options the treatment of verruca vulgaris remains difficult and various treatment modalities are accompanied with substantial pain, tissue destruction and frequent recurrence. Recently imiquimod has been successfully used as topical immune response modifier for the treatment of external anogenital warts with less pain, destruction and fewer recurrent rate. We observed a case of verruca vulgaris on the left palm and the left second toe in a 57-year-old man. He had been treated with keratolytic agent and CO2 laser with little effect. So we tried to treat him with 5% imiquimod cream which was self-applied to the lesions and achieved complete clearance after 4 weeks of the therapy.

A Case of Apocrine Type of Cutaneous Mixed Tumor with Follicular Differentiation / 대한피부과학회지

Mixed tumor of the skin or chondroid syringoma is a benign neoplasm characterized by histological features of a mixture of epithelial and mesenchymal components. Mixed tumor could be divided into two distinct types, eccrine and apocrine. We report a 59-year-old man with a 2X1 cm sized nodule on the right upper eyebrow. Histologically, it showed typical features of mixed tumor with tubules exhibiting branching and cystic dilatation in the myxoid and chondroid stroma. We observed apocrine type of cutaneous mixed tumor with follicular differentiation.

Nail Abnormalities in Alopecia Areata / 대한피부과학회지

BACKGROUND: Nail abnormalities may be associated with alopecia areata and nail abnormalities in alopecia areata are reported to range from 10%-66%. OBJECTIVES: This study investigates the clinical characteristics of nail abnormalities in alopecia areata, such as prevalence depending on sex, age and severities of hair loss. METHODS: Prospective analysis was undertaken by examining the finger nails of 424 alopecia areata patients and the nails of 465 non-alopecic patients were examined as controls. RESULTS: The number of the patients was 424(214 males, 210 females) and their mean age was 28.6 years (range 1-69). Nail abnormalities were noted in 98 (23.1%) out of 424 patients and in 24 (5.1%) out of 465 controls. According to age group, the prevalence of nail abnormalities was high at age under 9(31.7%) and at age of 10-19 (31.6%). The incidence according to severity of hair loss was 20.8% in below 50% of hair loss on scalp, 27.8% in 51%-100% of hair loss on scalp and 41.5% in 51%-100% of hair loss on the scalp and also involving body hair. The Frequent nail abnormalities were leukonychia punctata (8.5%) and pitting nail(8.0%). The other minor nail abnormalities were onychorrhexis, transverse ridging, trachyonychia, melanonychia, abnormality of lunula, onycholysis and koilonychia. CONCLUSIONS: The incidence of nail abnormalities in alopecia areata was significantly higher than in controls and the nail abnormalities were more common in children. The more severe was the degree of alopecia, the higher was the prevalence of nail abnormalities. Leukonychia punctata and pitting nail were frequently found in alopeica areata in Korea. The examination of nail in alopecia areata patients may be helpful in expectation of prognosis.

A Case of Nevus Sebaceus associated with Syringocystadenoma Papilliferum, Trichoblastoma, Basal Cell Carcinoma, Sebaceous Adenoma and Sebaceous Epithelioma / 대한피부과학회지

Nevus Sebaceus is a hamartoma that has a well-documented neoplastic potential. Multiple tumors may occasionally arise, but the coexistence of 3 or more tumors is extremely rare. We report a case of nevus sebaceus in a 55-year-old female associated with syringocystadenoma papilliferum, trichoblastoma, basal cell carcinoma, sebaceous adenoma and sebaceous epithelioma.

Two Cases of Pigmented Bowen's Disease

Pigmented Bowen's disease (PBD) is a rare variant of Bowen's disease(BD). Most of the reported cases showed pigmented patches or thin plaques. Thus its clinical manifestations may simulated other various pigmented skin lesions. We experienced 2 cases of PBD in patients with multiple BD developed after taking Korean proprietary pills (KPP, "Hwan-Yak"), which were suspected to contain certain amount of arsenics. Both patients also showed arsenical keratosis on their palms and soles. The darker pigmentation of the PBL led us to differentiated them from melanoma.

Concurrent Appearance of Alopecia Areata in Four Siblings / 대한피부과학회지

Familial occurrence of alopecia areata is not uncommon. A positive family history ranging among 10% to 40% has been reported from different surveys. A prevalence of 3% has been observed among siblings. The simultaneous onset of the disease in four siblings is, however, rare. We report the concurrent appearance of alopecia areata in four siblings and suggest emotional and genetic factors as possible causes.

A Case of Pigmented Basal Cell Carcinoma on the Scrotum / 대한피부과학회지

Basal cell carcinoma(BCC) is the most common cancer of the skin in Korea. The lesions are most frequently found in the head and neck regions. However, its appearance on the scrotal skin is rare. We observed a case of pigmented BCC on the scrotum in a 66-year-old man. He had a well circumscribed, brown-black plaque on the scrotum for 5 years and the history of prior vasectomy about 30 years ago. The cancer was excised widely.

A Case of Netherton's Syndrome / 대한피부과학회지

Netherton's syndrome is a rare autosomal recessive disorder characterized by the concurrence of ichthyosis, structural hair shaft abnormality, and atopy. The pathognomonic finding is that of trichorrhexis invaginata identified by light and scanning electron microscopic examination of hair shaft. We herein report a case of Netherton's syndrome in a 51-year-old woman who had polycyclic, serpiginous and erythematous patches with a characteristic, migratory, double-edged scale at the margins as a skin manifestation and trichorrhexis invaginata as a hair defect.

A Case of Netherton's Syndrome / 대한피부과학회지

Netherton's syndrome is a rare autosomal recessive disorder characterized by the concurrence of ichthyosis, structural hair shaft abnormality, and atopy. The pathognomonic finding is that of trichorrhexis invaginata identified by light and scanning electron microscopic examination of hair shaft. We herein report a case of Netherton's syndrome in a 51-year-old woman who had polycyclic, serpiginous and erythematous patches with a characteristic, migratory, double-edged scale at the margins as a skin manifestation and trichorrhexis invaginata as a hair defect.

Characteristics of Atopic Dermatitis Related to Ocular Complications / 대한피부과학회지

BACKGROUND: Long-standing atopic dermatitis patients frequently predispose to ocular complications. The ectodermal origin of the epidermis and of many eye structures explain the frequent associations observed in atopic dermatitis. OBJECTIVE: This study may help in evolving early diagnosis and in formulating standard therapeutic strategies to prevent and treat ocular complications by studying the types, frequency and dermatological characteristics of each ocular complication in atopic dermatitis. METHODS: We evaluated the ocular complications of 41 typical atopic dermatitis patients(26 males, 15 females) who had skin lesion around eyelids or complained of ocular symptoms. RESULTS: Mean age of the patients was 17.7 years. The onset of atopic dermatitis was during infancy in 21 patients, during childhood in 15 patients, and during adult in 5 patients and their mean duration of disease was 13.8 years. Mild ocular involvements including blepharitis in 29 patients(58 eyes, 70.7%), keratoconjunctivitis in 29 patients(58 eyes, 70.7%) were seen. More serious complications which may lead to decreased visual function including cataracts in 5 patients(10 eyes, 12.1%), retinal detachments in 3 patients(5 eyes, 6.0%) were seen. All the patients who had these two serious complications had facial dermatitis. And other ocular involvements including keratoconus in 2 patients(2 eyes, 2.4%), ocular herpes simplex in 1 patient(2 eyes, 2.4%), uveitis in 2 patients(2 eyes, 2.4%) were seen. CONCLUSION: It is important to perform an ophthalmologic examination in the early period of disease in long-standing atopic dermatitis patients especially those who have facial dermatitis for the early diagnosis and treatment of serious sight-threatening complications.

A Case of Polypoid Basal Cell Carcinoma / 대한피부과학회지

Basal cell carcinoma(BCC) is a most common malignant tumor of the skin and has many different clinical and histological appearances. Polypoid BCC is a new clinicopathological variant of BCC. Polypoid BCC is clinically distinguished by being pedunculated and having a stalk that connects it to the skin surface. Histologically, it is distinctive in that the tumor aggregations are restricted to the exophytic polypoid zone. We herein report a case of polypoid BCC in a 39-year-old man who had a single, asymptomatic, black-brownish, pedunculated mass on his right temple.

Epidemiologic and Clinical Survey of Behcet's Disease in Korea: the First Multicenter Study

The prevalence of Behcet's disease is the highest in the East Asian and the Medi-terranean countries. Behcet's disease is also distributed in the Asian countries, but the nationwide survey has not been performed in Korea yet. The Korean Study Group for Behcet's Disease, founded in 1999, conducted a multicenter, retrospective survey on epidemiologic and clinical features of the patients with Behcet's disease from 20 hospitals around the nation from 1997 to 1999. Of 3,497 patients, 1,527 were classified into complete or incomplete type of Behcet's disease according to the revised Shimizu's classification. The sex ratio was 1:1.75 with the female predominance. Geographical distribution showed the highest frequency in Seoul (38.5%). Clinically, 98.8% had oral ulcers, 83.2% had genital ulcers, 84.3% had skin lesions and 50.9% had ocular lesions. As for the minor clinical manifestations, articular symptoms were the most frequent. The pathergy test showed positive in 15.4% of patients and revealed a higher positive rate in males (20.2%) than in females (12.7%). In conclusion, we performed the first multicenter study on Behcet's disease in Korea and revealed the female predominance, higher frequency of ocular lesions, and lower positivity of pathergy test in the patients.

A case of Hairy Elbows Syndrome / 대한피부과학회지

Hypertrichosis cubiti, also named hairy elbows syndrome, circumscribed hypertrichosis in which a remarkable amount of long vellus hair is localized on the extensor surfaces of the upper extremities. We report a case of hairy elbows syndrome in a 12-year-old female patient, who was treated for short stature in pediatrics. She was referred to our department because of hypertrichosis of both elbows. Her height is 131cm, it is below 3 percentile of that of age. We could not find any physical abnormalities and other developmental disorders except short stature. But, Her intelligence is somewhat delayed comparative to that of age. She denied her family history about that. The literature on this subject is reviewed, and some clinical and etiopathogenic aspects are discussed.

A Case of Hereditary Epidermolytic Palmoplantar Keratoderma in Four Consecutive Generations / 대한피부과학회지

We observed a family with 12 members in four consecutive generations affected by hereditary epidermolytic palmoplantar keratoderma(HEPPK). The affected family members demonstrated not only autosomal dominant inheritance, but also a high penetrance and constant expression. The lesion of all affected person had developed at birth or within the first few weeks of life. The lesions of three members(the proband, her sister and mother) were biopsed, and all of them showed the characteristic features of epidermolytic hyperkeratosis. Two of family members(the proband, her nephew-not affected by HEPPK) had vitiligo, but we concluded that this coexistance was accidental.